TWIK related potassium channel (TREK)
REACTOME PATHWAYThe TWIK related potassium channel (TREK) pathway (Reactome ID: R-HSA-1299503) involves 3 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting TWIK related potassium channel (TREK)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Arachidonic Acid | — | 245 |
| 2 | Carvedilol | — | 296 |
| 3 | Riluzole | — | 298 |
| 4 | Amlodipine | — | 1,000 |
| 5 | Flunarizine Flunarizine is | — | 299 |
| 6 | Fluspirilene | — | 74 |
| 7 | Dehydroepiandrosterone Sulfate | — | 300 |
| 8 | Linoleic Acid | — | 300 |
| 9 | Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes | — | 300 |
| 10 | Quinidine | — | 298 |
About the TWIK related potassium channel (TREK) Pathway
The TWIK related potassium channel (TREK) pathway is catalogued in Reactome (ID: R-HSA-1299503) and involves 3 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KCNK10, KCNK2, KCNK4.