Defensins
REACTOME PATHWAYThe Defensins pathway (Reactome ID: R-HSA-1461973) involves 4 genes and is affected by 8 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defensins
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bortezomib | — | 300 |
| 2 | Sulfaguanidine | — | 255 |
| 3 | Calcimycin | — | 216 |
| 4 | Disulfiram | — | 297 |
| 5 | Oxyphenbutazone | — | 300 |
| 6 | Sphingosine | — | 300 |
| 7 | Myristic Acid | — | 300 |
| 8 | Palmitic Acid | — | 300 |
About the Defensins Pathway
The Defensins pathway is catalogued in Reactome (ID: R-HSA-1461973) and involves 4 genes. In the BiohacksAI corpus, 8 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCR6, PRSS2, PRSS3, TLR2.