ARMS-mediated activation
REACTOME PATHWAYThe ARMS-mediated activation pathway (Reactome ID: R-HSA-170984) involves 3 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting ARMS-mediated activation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Quercetin | — | 300 |
| 3 | Vemurafenib | — | 298 |
| 4 | Dasatinib | — | 299 |
| 5 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 6 | Crizotinib | — | 298 |
| 7 | Axitinib | — | 298 |
| 8 | pictilisib | — | 25 |
| 9 | sp600125 | — | 117 |
About the ARMS-mediated activation Pathway
The ARMS-mediated activation pathway is catalogued in Reactome (ID: R-HSA-170984) and involves 3 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, NTRK1, YWHAB.