Activation of ATR in response to replication stress
REACTOME PATHWAYThe Activation of ATR in response to replication stress pathway (Reactome ID: R-HSA-176187) involves 4 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activation of ATR in response to replication stress
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | sp600125 | — | 117 |
| 3 | alsterpaullone | — | 12 |
| 4 | Aurintricarboxylic Acid | — | 184 |
| 5 | Methylergonovine | — | 14 |
| 6 | plumbagin [Supplementary Concept] | — | 300 |
| 7 | Vitamin K 3 | — | 300 |
About the Activation of ATR in response to replication stress Pathway
The Activation of ATR in response to replication stress pathway is catalogued in Reactome (ID: R-HSA-176187) and involves 4 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC25A, CDC7, CDK2, CHEK1.