What compounds target CDK2?

BiohacksAI has identified 81 compounds that interact with CDK2 (cyclin dependent kinase 2). Top compounds include: erlotinib, seliciclib, lapatinib, alvocidib, palbociclib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CDK2 (cyclin dependent kinase)?

CDK2 is cyclin dependent kinase 2. It is a molecular target for 81 compounds documented in PubMed bioassay data. NCBI Gene ID: 1017.

CDK2

MOLECULAR TARGET

cyclin dependent kinase 2

NCBI Gene: 101781 compounds

CDK2 (cyclin dependent kinase 2) is targeted by 81 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CDK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	seliciclib	4.91	135
3	lapatinib	4.84	126
4	alvocidib	4.52	91
5	palbociclib	4.22	67
6	ceritinib	4.19	65
7	dinaciclib	3.87	47
8	silmitasertib	3.78	43
9	olomoucine	3.71	40
10	abemaciclib	3.66	38
11	nintedanib	3.61	36
12	wogonin	3.61	36
13	bms 387032	3.47	31
14	tae 684	3.43	30
15	saracatinib	3.33	27
16	at 7519	3.33	27
17	dabrafenib	3.30	26
18	ribociclib	3.26	25
19	sp 600125	3.22	24
20	purvalanola	3.18	23
21	pyrogallol	3.14	22
22	jnj 7706621	3.09	21
23	lestaurtinib	3.04	20
24	danusertib	2.94	18
25	salirasib	2.94	18
26	momelotinib	2.89	17
27	k 252a	2.83	16
28	su 9516	2.83	16
29	milciclib	2.77	15
30	pf 00562271	2.77	15
31	6 benzylaminopurine	2.77	15
32	pha 665752	2.71	14
33	crenolanib	2.71	14
34	azd 5438	2.71	14
35	closantel	2.71	14
36	ast 487	2.56	12
37	zotiraciclib	2.56	12
38	atuveciclib	2.56	12
39	roniciclib	2.56	12
40	indazole	2.56	12
41	defactinib	2.48	11
42	5 nitro 2 phenylpropylaminobenzoic acid nppb	2.40	10
43	rebastinib	2.20	8
44	ct 7001	2.20	8
45	acid blue 25	2.20	8
46	cyc 116	2.08	7
47	enzastaurin	2.08	7
48	rg 547	2.08	7
49	gsk 269962a	2.08	7
50	purvalanol b	2.08	7

Showing top 50 of 81 compounds. Use the BiohacksAI search to explore all CDK2 modulators.

About CDK2 as a Drug Target

CDK2 (cyclin dependent kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 81 compounds with documented CDK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CDK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.