NGF-independant TRKA activation
REACTOME PATHWAYThe NGF-independant TRKA activation pathway (Reactome ID: R-HSA-187024) involves 2 genes and is affected by 6 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting NGF-independant TRKA activation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | Sorafenib | — | 300 |
| 3 | sp600125 | — | 117 |
| 4 | Axitinib | — | 298 |
| 5 | pictilisib | — | 25 |
| 6 | tyrosol | — | 300 |
About the NGF-independant TRKA activation Pathway
The NGF-independant TRKA activation pathway is catalogued in Reactome (ID: R-HSA-187024) and involves 2 genes. In the BiohacksAI corpus, 6 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NTRK1, NTRK2.