VEGF ligand-receptor interactions
REACTOME PATHWAYThe VEGF ligand-receptor interactions pathway (Reactome ID: R-HSA-194313) involves 3 genes and is affected by 11 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting VEGF ligand-receptor interactions
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | kenpaullone | — | 8 |
| 4 | sp600125 | — | 117 |
| 5 | Crizotinib | — | 298 |
| 6 | Quercetin | — | 300 |
| 7 | Avapritinib | — | 246 |
| 8 | Dasatinib | — | 299 |
| 9 | tyrphostin ag 1295 | — | 1 |
| 10 | Vemurafenib | — | 298 |
| 11 | alsterpaullone | — | 12 |
About the VEGF ligand-receptor interactions Pathway
The VEGF ligand-receptor interactions pathway is catalogued in Reactome (ID: R-HSA-194313) and involves 3 genes. In the BiohacksAI corpus, 11 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FLT1, FLT4, KDR.