Cobalamin (Cbl, vitamin B12) transport and metabolism
REACTOME PATHWAYThe Cobalamin (Cbl, vitamin B12) transport and metabolism pathway (Reactome ID: R-HSA-196741) involves 4 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Cobalamin (Cbl, vitamin B12) transport and metabolism
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bortezomib | — | 300 |
| 2 | Sulfaguanidine | — | 255 |
| 3 | Daunorubicin | — | 298 |
| 4 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 5 | Kaempferols | — | 300 |
| 6 | Quercetin | — | 300 |
| 7 | Rimonabant | — | 300 |
| 8 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 9 | Kaempferols | — | 300 |
| 10 | Abacavir | — | 295 |
| 11 | Dehydroepiandrosterone Sulfate | — | 300 |
| 12 | Delavirdine | — | 296 |
| 13 | Emtricitabine | — | 292 |
| 14 | Flurandrenolone | — | 65 |
| 15 | Indomethacin | — | 297 |
| 16 | Lamivudine | — | 299 |
| 17 | tiopronin | — | 299 |
| 18 | Triamcinolone | — | 300 |
| 19 | Triamcinolone Acetonide | — | 300 |
About the Cobalamin (Cbl, vitamin B12) transport and metabolism Pathway
The Cobalamin (Cbl, vitamin B12) transport and metabolism pathway is catalogued in Reactome (ID: R-HSA-196741) and involves 4 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, CTRB1, PRSS1, PRSS3.