Cell death signalling via NRAGE, NRIF and NADE
REACTOME PATHWAYThe Cell death signalling via NRAGE, NRIF and NADE pathway (Reactome ID: R-HSA-204998) involves 10 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Cell death signalling via NRAGE, NRIF and NADE
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dihydroergocristine | — | 187 |
| 2 | Anisomycin | — | 247 |
| 3 | sp600125 | — | 117 |
| 4 | pictilisib | — | 25 |
| 5 | Axitinib | — | 298 |
| 6 | cardamonin | — | 180 |
| 7 | Hesperidin | — | 300 |
| 8 | Spermine | — | 300 |
| 9 | Cetylpyridinium Cationic bactericidal surfactant used as | — | 300 |
| 10 | egcg | — | 300 |
About the Cell death signalling via NRAGE, NRIF and NADE Pathway
The Cell death signalling via NRAGE, NRIF and NADE pathway is catalogued in Reactome (ID: R-HSA-204998) and involves 10 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APH1A, APH1B, BAD, BCL2L11, CASP2.