Activated NOTCH1 Transmits Signal to the Nucleus
REACTOME PATHWAYThe Activated NOTCH1 Transmits Signal to the Nucleus pathway (Reactome ID: R-HSA-2122948) involves 10 genes and is affected by 11 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activated NOTCH1 Transmits Signal to the Nucleus
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dihydroergocristine | — | 187 |
| 2 | Bisphenol A-Glycidyl Methacrylate | — | 197 |
| 3 | Kaempferols | — | 300 |
| 4 | Progesterone | — | 299 |
| 5 | Hexachlorophene | — | 300 |
| 6 | aniracetam | — | 110 |
| 7 | Nadolol | — | 297 |
| 8 | Nicardipine | — | 94 |
| 9 | Prednisolone | — | 1,000 |
| 10 | Axitinib | — | 298 |
| 11 | Crizotinib | — | 298 |
About the Activated NOTCH1 Transmits Signal to the Nucleus Pathway
The Activated NOTCH1 Transmits Signal to the Nucleus pathway is catalogued in Reactome (ID: R-HSA-2122948) and involves 10 genes. In the BiohacksAI corpus, 11 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, APH1A, APH1B, ARRB1.