PRC2 methylates histones and DNA
REACTOME PATHWAYThe PRC2 methylates histones and DNA pathway (Reactome ID: R-HSA-212300) involves 5 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting PRC2 methylates histones and DNA
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | s adenosylhomocysteine | — | 300 |
| 2 | egcg | — | 300 |
| 3 | Oleic Acid | — | 112 |
| 4 | Anthralin | — | 299 |
| 5 | Azacitidine | — | 298 |
| 6 | Azacitidine | — | 300 |
| 7 | Carboxin | — | 174 |
| 8 | Cefdinir | — | 298 |
| 9 | Cefixime | — | 300 |
| 10 | Decitabine | — | 298 |
| 11 | Fluorometholone | — | 299 |
| 12 | Oxytetracycline | — | 300 |
| 13 | Uridine | — | 300 |
| 14 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 15 | Quercetin | — | 300 |
| 16 | Biotin | — | 297 |
| 17 | Sorafenib | — | 300 |
| 18 | scutellarein | — | 113 |
| 19 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
About the PRC2 methylates histones and DNA Pathway
The PRC2 methylates histones and DNA pathway is catalogued in Reactome (ID: R-HSA-212300) and involves 5 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DNMT1, DNMT3B, EED, EZH1, EZH2.