TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACTOME PATHWAYThe TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway (Reactome ID: R-HSA-2173791) involves 4 genes and is affected by 13 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | Arachidonic Acid | — | 245 |
| 3 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 4 | alsterpaullone | — | 12 |
| 5 | Sphingosine | — | 300 |
| 6 | Sirolimus | — | 300 |
| 7 | cycloheximide | — | 300 |
| 8 | Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against | — | 299 |
| 9 | Everolimus | — | 297 |
| 10 | Hesperidin | — | 300 |
| 11 | Sorafenib | — | 300 |
| 12 | Vemurafenib | — | 298 |
| 13 | Crizotinib | — | 298 |
About the TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Pathway
The TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway is catalogued in Reactome (ID: R-HSA-2173791) and involves 4 genes. In the BiohacksAI corpus, 13 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FKBP1A, PRKCZ, TGFBR1, TGFBR2.