Signaling by NOTCH1 HD Domain Mutants in Cancer
REACTOME PATHWAYThe Signaling by NOTCH1 HD Domain Mutants in Cancer pathway (Reactome ID: R-HSA-2691230) involves 2 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Signaling by NOTCH1 HD Domain Mutants in Cancer
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bisphenol A-Glycidyl Methacrylate | — | 197 |
| 2 | Kaempferols | — | 300 |
| 3 | Progesterone | — | 299 |
| 4 | Hexachlorophene | — | 300 |
| 5 | Prednisolone | — | 1,000 |
About the Signaling by NOTCH1 HD Domain Mutants in Cancer Pathway
The Signaling by NOTCH1 HD Domain Mutants in Cancer pathway is catalogued in Reactome (ID: R-HSA-2691230) and involves 2 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17.