GRB2:SOS provides linkage to MAPK signaling for Integrins
REACTOME PATHWAYThe GRB2:SOS provides linkage to MAPK signaling for Integrins pathway (Reactome ID: R-HSA-354194) involves 4 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting GRB2:SOS provides linkage to MAPK signaling for Integrins
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in | — | 299 |
| 2 | Dasatinib | — | 299 |
| 3 | Resveratrol | — | 298 |
| 4 | tyrphostin ag 1478 | — | 4 |
| 5 | Sorafenib | — | 300 |
| 6 | Quercetin | — | 300 |
| 7 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 8 | Afatinib | — | 297 |
| 9 | alsterpaullone | — | 12 |
| 10 | Crizotinib | — | 298 |
| 11 | kenpaullone | — | 8 |
| 12 | monorden | — | 8 |
| 13 | Niclosamide | — | 299 |
| 14 | Dactinomycin | — | 297 |
About the GRB2:SOS provides linkage to MAPK signaling for Integrins Pathway
The GRB2:SOS provides linkage to MAPK signaling for Integrins pathway is catalogued in Reactome (ID: R-HSA-354194) and involves 4 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, ITGA2B, ITGB3, SRC.