ATF6 (ATF6-alpha) activates chaperones
REACTOME PATHWAYThe ATF6 (ATF6-alpha) activates chaperones pathway (Reactome ID: R-HSA-381033) involves 4 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting ATF6 (ATF6-alpha) activates chaperones
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate). | — | 300 |
| 2 | fluoranthene | — | 300 |
| 3 | Ethoxyquin Antioxidant; also | — | 180 |
| 4 | Methylcholanthrene | — | 300 |
| 5 | Mometasone Furoate | — | 292 |
| 6 | Masoprocol | — | 300 |
| 7 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
| 8 | Adenosine Triphosphate | — | 300 |
| 9 | Hexachlorophene | — | 300 |
| 10 | Ergosterol | — | 300 |
| 11 | Calcimycin | — | 216 |
| 12 | Fluspirilene | — | 74 |
About the ATF6 (ATF6-alpha) activates chaperones Pathway
The ATF6 (ATF6-alpha) activates chaperones pathway is catalogued in Reactome (ID: R-HSA-381033) and involves 4 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATF6, HSP90B1, HSPA5, XBP1.