What compounds affect the XBP1(S) activates chaperone genes pathway?

18 compounds in the BiohacksAI corpus have documented interactions with genes in the XBP1(S) activates chaperone genes pathway (Reactome ID: R-HSA-381038). These compounds target 3 genes within this pathway.

What genes are in the XBP1(S) activates chaperone genes pathway?

The XBP1(S) activates chaperone genes pathway involves 3 genes. Key genes include: GSK3A, LMNA, XBP1.

XBP1(S) activates chaperone genes

REACTOME PATHWAY

Reactome: R-HSA-3810383 genes18 compounds

The XBP1(S) activates chaperone genes pathway (Reactome ID: R-HSA-381038) involves 3 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GSK3A LMNA XBP1

Compounds Affecting XBP1(S) activates chaperone genes

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	indirubin	—	300
3	kenpaullone	—	8
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	chrysin	—	300
7	fisetin	—	78
8	Kaempferols	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Quercetin	—	300
11	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
12	Chlorhexidine	—	299
13	piceatannol	—	300
14	sp600125	—	117
15	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
16	Calcimycin	—	216
17	Fluspirilene	—	74
18	Histamine	—	300

About the XBP1(S) activates chaperone genes Pathway

The XBP1(S) activates chaperone genes pathway is catalogued in Reactome (ID: R-HSA-381038) and involves 3 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GSK3A, LMNA, XBP1.