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Histamine

An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

300+ PubMed studies analyzed · 4 RCTs · Evidence Score: 42.3

Research Domains

Histamine has been studied across 20 research domains including 🛡️ Immunity, 🦠 Gut & Microbiome, 🫁 Respiratory, 🔬 Oncology, 🔬 Inflammation. The primary research focus is 🛡️ Immunity with 8% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Histamine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Indapamide
11 shared targets
Chlorthalidone
9 shared targets
Zonisamide
10 shared targets
Famotidine
11 shared targets
Metolazone
9 shared targets
stx64
10 shared targets
benzolamide
9 shared targets
Histidine
9 shared targets
topiramate
8 shared targets
brinzolamide
8 shared targets
Loading evidence profile...

This evidence profile for Histamine is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.