What genes are in the Thromboxane signalling through TP receptor pathway?

The Thromboxane signalling through TP receptor pathway involves 2 genes. Key genes include: GNA15, TBXA2R.

Thromboxane signalling through TP receptor

Q: What compounds affect the Thromboxane signalling through TP receptor pathway?

32 compounds in the BiohacksAI corpus have documented interactions with genes in the Thromboxane signalling through TP receptor pathway (Reactome ID: R-HSA-428930). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4289302 genes32 compounds

The Thromboxane signalling through TP receptor pathway (Reactome ID: R-HSA-428930) involves 2 genes and is affected by 32 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GNA15 TBXA2R

Compounds Affecting Thromboxane signalling through TP receptor

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Dinoprost	—	252
3	Dinoprostone	—	296
4	Amlodipine	—	1,000
5	cbd	—	298
6	Losartan	—	1,000
7	Simvastatin	—	1,000
8	Axitinib	—	298
9	candesartan cilexetil [Supplementary Concept]	—	300
10	cannabidiol	—	296
11	Cloprostenol	—	300
12	Enoxacin	—	299
13	Epirubicin	—	300
14	Ezetimibe	—	296
15	Flutamide	—	298
16	Irbesartan	—	298
17	Micafungin	—	300
18	Nicergoline	—	300
19	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
20	Pioglitazone	—	297
21	Rifamycins	—	300
22	Rifamycins	—	300
23	Ritonavir	—	298
24	Thiethylperazine	—	165
25	Ticagrelor	—	299
26	Bisphenol A-Glycidyl Methacrylate	—	197
27	Calcimycin	—	216
28	Equilin	—	216
29	Fluspirilene	—	74
30	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
31	Sphingosine	—	300
32	Astemizole Antihistamine drug now withdrawn from	—	280

About the Thromboxane signalling through TP receptor Pathway

The Thromboxane signalling through TP receptor pathway is catalogued in Reactome (ID: R-HSA-428930) and involves 2 genes. In the BiohacksAI corpus, 32 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GNA15, TBXA2R.