Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
REACTOME PATHWAYThe Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway (Reactome ID: R-HSA-446193) involves 5 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Zanamivir | — | 297 |
| 2 | caffeic acid | — | 300 |
| 3 | egcg | — | 300 |
| 4 | Rutin | — | 300 |
| 5 | Metergoline | — | 144 |
| 6 | Methyldopa | — | 297 |
| 7 | Oxytetracycline | — | 300 |
| 8 | streptonigrin | — | 299 |
| 9 | Tolazamide | — | 169 |
| 10 | Oseltamivir | — | 297 |
| 11 | Methotrexate | — | 289 |
| 12 | Bortezomib | — | 300 |
About the Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Pathway
The Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway is catalogued in Reactome (ID: R-HSA-446193) and involves 5 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CTSA, MPI, NEU2, NEU3, SLC17A5.