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Amethopterin

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

289+ PubMed studies analyzed · Evidence Score: 42.1

Research Domains

Amethopterin has been studied across 15 research domains including 🔬 Oncology, 🫁 Liver & Detox, 🧠 Focus & Attention, 🦠 Gut & Microbiome, ✨ Skin & Hair. The primary research focus is 🔬 Oncology with 24% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Amethopterin, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Cytarabine
21 shared targets
Pemetrexed
14 shared targets
Melphalan
23 shared targets
Trifluridine
19 shared targets
vinblastine
26 shared targets
cycloheximide
26 shared targets
Azathioprine
19 shared targets
Azacitidine
21 shared targets
Azacitidine
21 shared targets
clofilium
18 shared targets
Loading evidence profile...

This evidence profile for Amethopterin is generated deterministically from 289 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.