VEGFR2 mediated cell proliferation
REACTOME PATHWAYThe VEGFR2 mediated cell proliferation pathway (Reactome ID: R-HSA-5218921) involves 5 genes and is affected by 20 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting VEGFR2 mediated cell proliferation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Quercetin | — | 300 |
| 2 | alsterpaullone | — | 12 |
| 3 | kenpaullone | — | 8 |
| 4 | Dasatinib | — | 299 |
| 5 | Sorafenib | — | 300 |
| 6 | Crizotinib | — | 298 |
| 7 | sp600125 | — | 117 |
| 8 | Sphingosine | — | 300 |
| 9 | Resveratrol | — | 298 |
| 10 | tyrphostin ag 1478 | — | 4 |
| 11 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 12 | Afatinib | — | 297 |
| 13 | monorden | — | 8 |
| 14 | Niclosamide | — | 299 |
| 15 | Axitinib | — | 298 |
| 16 | Avapritinib | — | 246 |
| 17 | tyrphostin ag 1295 | — | 1 |
| 18 | Vemurafenib | — | 298 |
| 19 | Arachidonic Acid | — | 245 |
| 20 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
About the VEGFR2 mediated cell proliferation Pathway
The VEGFR2 mediated cell proliferation pathway is catalogued in Reactome (ID: R-HSA-5218921) and involves 5 genes. In the BiohacksAI corpus, 20 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KDR, PDPK1, PRKCZ, SPHK1, SRC.