N-glycan trimming in the ER and Calnexin/Calreticulin cycle
REACTOME PATHWAYThe N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway (Reactome ID: R-HSA-532668) involves 4 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting N-glycan trimming in the ER and Calnexin/Calreticulin cycle
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Hexachlorophene | — | 300 |
| 2 | Oxytetracycline | — | 300 |
| 3 | egcg | — | 300 |
| 4 | Clotrimazole | — | 296 |
| 5 | Demeclocycline | — | 5 |
| 6 | Edaravone | — | 298 |
| 7 | 1-Deoxynojirimycin | — | 299 |
| 8 | Bortezomib | — | 300 |
| 9 | juglone hydroxylase [Supplementary Concept] catalyzes | — | 279 |
About the N-glycan trimming in the ER and Calnexin/Calreticulin cycle Pathway
The N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway is catalogued in Reactome (ID: R-HSA-532668) and involves 4 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GANAB, PDIA3, PSMC1, VCP.