Caspase activation via extrinsic apoptotic signalling pathway
REACTOME PATHWAYThe Caspase activation via extrinsic apoptotic signalling pathway pathway (Reactome ID: R-HSA-5357769) involves 4 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Caspase activation via extrinsic apoptotic signalling pathway
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | sp600125 | — | 117 |
| 3 | Kaempferols | — | 300 |
| 4 | Quercetin | — | 300 |
| 5 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 6 | Methylene Blue | — | 200 |
| 7 | felbinac | — | 31 |
About the Caspase activation via extrinsic apoptotic signalling pathway Pathway
The Caspase activation via extrinsic apoptotic signalling pathway pathway is catalogued in Reactome (ID: R-HSA-5357769) and involves 4 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP9, DAPK1, DAPK2, DAPK3.