TNFR1-induced proapoptotic signaling
REACTOME PATHWAYThe TNFR1-induced proapoptotic signaling pathway (Reactome ID: R-HSA-5357786) involves 3 genes and is affected by 4 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting TNFR1-induced proapoptotic signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | amlexanox | — | 96 |
| 2 | Crizotinib | — | 298 |
| 3 | Axitinib | — | 298 |
| 4 | Gliotoxin | — | 300 |
About the TNFR1-induced proapoptotic signaling Pathway
The TNFR1-induced proapoptotic signaling pathway is catalogued in Reactome (ID: R-HSA-5357786) and involves 3 genes. In the BiohacksAI corpus, 4 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IKBKE, RBCK1, TBK1.