IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
REACTOME PATHWAYThe IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) pathway (Reactome ID: R-HSA-5603027) involves 2 genes and is affected by 6 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | chicoric acid | — | 117 |
| 2 | alsterpaullone | — | 12 |
| 3 | Aurintricarboxylic Acid | — | 184 |
| 4 | Crizotinib | — | 298 |
| 5 | sp600125 | — | 117 |
| 6 | glaucarubinone | — | 10 |
About the IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Pathway
The IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) pathway is catalogued in Reactome (ID: R-HSA-5603027) and involves 2 genes. In the BiohacksAI corpus, 6 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB.