Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
REACTOME PATHWAYThe Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) pathway (Reactome ID: R-HSA-5619099) involves 2 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Arginine Vasopressin | — | 298 |
| 2 | Oxytocin | — | 299 |
| 3 | Deamino Arginine Vasopressin | — | 46 |
| 4 | Ornipressin | — | 82 |
| 5 | Lypressin | — | 24 |
| 6 | Amdinocillin | — | 100 |
| 7 | Aripiprazole | — | 298 |
| 8 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 9 | Calcimycin | — | 216 |
| 10 | Daunorubicin | — | 298 |
| 11 | Ritonavir | — | 298 |
| 12 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
About the Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Pathway
The Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) pathway is catalogued in Reactome (ID: R-HSA-5619099) and involves 2 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AVPR1A, AVPR1B.