What compounds affect the Diseases of metabolism pathway?

199 compounds in the BiohacksAI corpus have documented interactions with genes in the Diseases of metabolism pathway (Reactome ID: R-HSA-5668914). These compounds target 29 genes within this pathway.

What genes are in the Diseases of metabolism pathway?

The Diseases of metabolism pathway involves 29 genes. Key genes include: ADA, ADAMTS4, ADAMTS5, AHCY, CTSA, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP1B1.

Diseases of metabolism

REACTOME PATHWAY

Reactome: R-HSA-566891429 genes199 compounds

The Diseases of metabolism pathway (Reactome ID: R-HSA-5668914) involves 29 genes and is affected by 199 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADA ADAMTS4 ADAMTS5 AHCY CTSA CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1B1 CYP24A1 DLD GAA GALK1 GALNS GALNT3 HPRT1 IDH1 LARGE1 MAOA MC2R MPI MUC1 PNP SI SLC34A2 TBXAS1 UGT1A1 UGT1A4

Compounds Affecting Diseases of metabolism

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	egcg	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Methylene Blue	—	200
6	streptonigrin	—	299
7	Rutin	—	300
8	Letrozole	—	298
9	Fadrozole	—	300
10	chrysin	—	300
11	Miconazole	—	298
12	Hexachlorophene	—	300
13	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Anastrozole	—	298
16	Kaempferols	—	300
17	Clotrimazole	—	296
18	Bortezomib	—	300
19	cycloheximide	—	300
20	Lovastatin	—	300
21	Astemizole Antihistamine drug now withdrawn from	—	280
22	Azacitidine	—	298
23	Azacitidine	—	300
24	Chlorhexidine	—	299
25	Digoxin	—	299
26	Dinitrochlorobenzene	—	300
27	Nisoldipine	—	297
28	Kaempferols	—	300
29	Simvastatin	—	1,000
30	Carbazilquinone	—	48
31	clofilium tosylate	—	4
32	Idazoxan	—	300
33	Lynestrenol	—	299
34	Vitamin K 3	—	300
35	Niclosamide	—	299
36	Salmeterol Xinafoate	—	227
37	Sorafenib	—	300
38	Thioridazine	—	35
39	vinblastine sulfate	—	81
40	licochalcone	—	267
41	Ethinyl Estradiol	—	300
42	plumbagin [Supplementary Concept]	—	300
43	scutellarein	—	113
44	1-Deoxynojirimycin	—	299
45	caffeic acid	—	300
46	piceatannol	—	300
47	Adenosine	—	298
48	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
49	guanine	—	299
50	Androstenedione	—	300

About the Diseases of metabolism Pathway

The Diseases of metabolism pathway is catalogued in Reactome (ID: R-HSA-5668914) and involves 29 genes. In the BiohacksAI corpus, 199 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADA, ADAMTS4, ADAMTS5, AHCY, CTSA.