Translation initiation complex formation
REACTOME PATHWAYThe Translation initiation complex formation pathway (Reactome ID: R-HSA-72649) involves 5 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Translation initiation complex formation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | egcg | — | 300 |
| 2 | Hexachlorophene | — | 300 |
| 3 | Oxytetracycline | — | 300 |
| 4 | Oxcarbazepine | — | 296 |
| 5 | Rosmarinic Acid | — | 300 |
| 6 | Rutin | — | 300 |
| 7 | Phenoxybenzamine | — | 21 |
| 8 | Anthralin | — | 299 |
| 9 | Cefixime | — | 300 |
| 10 | Ethidium | — | 300 |
| 11 | sp600125 | — | 117 |
| 12 | Temozolomide | — | 299 |
| 13 | Metronidazole | — | 300 |
| 14 | Corticosterone | — | 300 |
| 15 | Diphenhydramine | — | 14 |
| 16 | DEAD-box RNA Helicases | — | 169 |
| 17 | Thioctic Acid | — | 298 |
| 18 | Thioctic Acid | — | 300 |
| 19 | Azauridine | — | 300 |
| 20 | Levetiracetam | — | 296 |
| 21 | cycloheximide | — | 300 |
| 22 | Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate). | — | 300 |
About the Translation initiation complex formation Pathway
The Translation initiation complex formation pathway is catalogued in Reactome (ID: R-HSA-72649) and involves 5 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF4A1, EIF4G1, EIF4H, PABPC1, RPSA.