GTP hydrolysis and joining of the 60S ribosomal subunit
REACTOME PATHWAYThe GTP hydrolysis and joining of the 60S ribosomal subunit pathway (Reactome ID: R-HSA-72706) involves 4 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting GTP hydrolysis and joining of the 60S ribosomal subunit
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | egcg | — | 300 |
| 2 | Hexachlorophene | — | 300 |
| 3 | Oxytetracycline | — | 300 |
| 4 | Metronidazole | — | 300 |
| 5 | Rosmarinic Acid | — | 300 |
| 6 | Rutin | — | 300 |
| 7 | Corticosterone | — | 300 |
| 8 | Diphenhydramine | — | 14 |
| 9 | Oxcarbazepine | — | 296 |
| 10 | Phenoxybenzamine | — | 21 |
| 11 | DEAD-box RNA Helicases | — | 169 |
| 12 | Thioctic Acid | — | 298 |
| 13 | Thioctic Acid | — | 300 |
| 14 | Azauridine | — | 300 |
| 15 | Levetiracetam | — | 296 |
| 16 | cycloheximide | — | 300 |
| 17 | Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate). | — | 300 |
About the GTP hydrolysis and joining of the 60S ribosomal subunit Pathway
The GTP hydrolysis and joining of the 60S ribosomal subunit pathway is catalogued in Reactome (ID: R-HSA-72706) and involves 4 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF4A1, EIF4G1, EIF4H, RPSA.