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BiohacksAI

Evidence-Based Biohacking

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Purine ribonucleoside monophosphate biosynthesis

REACTOME PATHWAY
Reactome: R-HSA-738174 genes4 compounds

The Purine ribonucleoside monophosphate biosynthesis pathway (Reactome ID: R-HSA-73817) involves 4 genes and is affected by 4 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATICGARTIMPDH1IMPDH2

Compounds Affecting Purine ribonucleoside monophosphate biosynthesis

#CompoundTargets HitStudies
1Pemetrexed—299
2Methotrexate—289
3Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of—300
4Inosine Monophosphate Inosine 5'-Monophosphate.—299

About the Purine ribonucleoside monophosphate biosynthesis Pathway

The Purine ribonucleoside monophosphate biosynthesis pathway is catalogued in Reactome (ID: R-HSA-73817) and involves 4 genes. In the BiohacksAI corpus, 4 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATIC, GART, IMPDH1, IMPDH2.