Purine salvage
REACTOME PATHWAYThe Purine salvage pathway (Reactome ID: R-HSA-74217) involves 6 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Purine salvage
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Adenosine | — | 298 |
| 2 | Coformycin | — | 171 |
| 3 | guanine | — | 299 |
| 4 | Deoxycytidine | — | 300 |
| 5 | Gemcitabine | — | 300 |
| 6 | Cladribine | — | 297 |
| 7 | Cytarabine | — | 297 |
| 8 | Cytidine | — | 300 |
| 9 | Toyocamycin 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is | — | 210 |
| 10 | Afatinib | — | 297 |
| 11 | Tubercidin | — | 300 |
| 12 | Pentostatin | — | 297 |
| 13 | Guanosine Monophosphate | — | 300 |
| 14 | Inosine Monophosphate Inosine 5'-Monophosphate. | — | 299 |
About the Purine salvage Pathway
The Purine salvage pathway is catalogued in Reactome (ID: R-HSA-74217) and involves 6 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADA, ADK, AMPD3, DCK, HPRT1.