IRS activation
REACTOME PATHWAYThe IRS activation pathway (Reactome ID: R-HSA-74713) involves 2 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting IRS activation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 3 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 4 | Sorafenib | — | 300 |
| 5 | sp600125 | — | 117 |
| 6 | Digitoxin | — | 300 |
| 7 | Digoxin | — | 299 |
| 8 | Flutamide | — | 298 |
| 9 | m084 | — | 2 |
| 10 | Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against | — | 299 |
About the IRS activation Pathway
The IRS activation pathway is catalogued in Reactome (ID: R-HSA-74713) and involves 2 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include INS, INSR.