Synthesis of active ubiquitin: roles of E1 and E2 enzymes
REACTOME PATHWAYThe Synthesis of active ubiquitin: roles of E1 and E2 enzymes pathway (Reactome ID: R-HSA-8866652) involves 2 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Synthesis of active ubiquitin: roles of E1 and E2 enzymes
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | alpha-Linolenic Acid | — | 300 |
| 2 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 3 | Quercetin | — | 300 |
| 4 | celastrol | — | 300 |
| 5 | Vemurafenib | — | 298 |
About the Synthesis of active ubiquitin: roles of E1 and E2 enzymes Pathway
The Synthesis of active ubiquitin: roles of E1 and E2 enzymes pathway is catalogued in Reactome (ID: R-HSA-8866652) and involves 2 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include USP5, USP7.