MET activates RAP1 and RAC1
REACTOME PATHWAYThe MET activates RAP1 and RAC1 pathway (Reactome ID: R-HSA-8875555) involves 2 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting MET activates RAP1 and RAC1
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | Afatinib | — | 297 |
| 3 | egcg | — | 300 |
| 4 | Axitinib | — | 298 |
| 5 | Sorafenib | — | 300 |
| 6 | Quercetin | — | 300 |
| 7 | Adenosine Triphosphate | — | 300 |
| 8 | sp600125 | — | 117 |
| 9 | Dactinomycin | — | 297 |
About the MET activates RAP1 and RAC1 Pathway
The MET activates RAP1 and RAC1 pathway is catalogued in Reactome (ID: R-HSA-8875555) and involves 2 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, MET.