What compounds affect the Nucleotide salvage pathway?

19 compounds in the BiohacksAI corpus have documented interactions with genes in the Nucleotide salvage pathway (Reactome ID: R-HSA-8956321). These compounds target 8 genes within this pathway.

What genes are in the Nucleotide salvage pathway?

The Nucleotide salvage pathway involves 8 genes. Key genes include: ADA, ADK, AMPD3, CDA, DCK, HPRT1, PNP, TK1.

Nucleotide salvage

REACTOME PATHWAY

Reactome: R-HSA-89563218 genes19 compounds

The Nucleotide salvage pathway (Reactome ID: R-HSA-8956321) involves 8 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADA ADK AMPD3 CDA DCK HPRT1 PNP TK1

Compounds Affecting Nucleotide salvage

#	Compound	Targets Hit	Studies
1	Adenosine	—	298
2	Coformycin	—	171
3	guanine	—	299
4	Deoxycytidine	—	300
5	Gemcitabine	—	300
6	Cladribine	—	297
7	Cytarabine	—	297
8	Cytidine	—	300
9	Toyocamycin 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is	—	210
10	Afatinib	—	297
11	Tubercidin	—	300
12	Pentostatin	—	297
13	Bromodeoxyuridine	—	300
14	Thymidine Monophosphate 5-Thymidylic acid.	—	202
15	Vidarabine	—	299
16	Guanosine Monophosphate	—	300
17	Inosine Monophosphate Inosine 5'-Monophosphate.	—	299
18	Tetrahydrouridine	—	166
19	Uridine	—	300

About the Nucleotide salvage Pathway

The Nucleotide salvage pathway is catalogued in Reactome (ID: R-HSA-8956321) and involves 8 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADA, ADK, AMPD3, CDA, DCK.