NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACTOME PATHWAYThe NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway (Reactome ID: R-HSA-933543) involves 2 genes and is affected by 6 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | chicoric acid | — | 117 |
| 2 | alsterpaullone | — | 12 |
| 3 | Aurintricarboxylic Acid | — | 184 |
| 4 | Crizotinib | — | 298 |
| 5 | sp600125 | — | 117 |
| 6 | glaucarubinone | — | 10 |
About the NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Pathway
The NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway is catalogued in Reactome (ID: R-HSA-933543) and involves 2 genes. In the BiohacksAI corpus, 6 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB.