Suppression of phagosomal maturation
REACTOME PATHWAYThe Suppression of phagosomal maturation pathway (Reactome ID: R-HSA-9637687) involves 3 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Suppression of phagosomal maturation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Nitroarginine | — | 300 |
| 2 | Arginine | — | 300 |
| 3 | Arginine | — | 300 |
| 4 | NG-Nitroarginine Methyl Ester | — | 238 |
| 5 | alyssin [Supplementary Concept] | — | 300 |
| 6 | Guanethidine | — | 300 |
| 7 | Chlorhexidine | — | 299 |
| 8 | Reserpine | — | 297 |
| 9 | Guanosine Diphosphate | — | 300 |
| 10 | Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate). | — | 300 |
About the Suppression of phagosomal maturation Pathway
The Suppression of phagosomal maturation pathway is catalogued in Reactome (ID: R-HSA-9637687) and involves 3 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KPNB1, NOS2, RAB7A.