Imatinib-resistant PDGFR mutants
REACTOME PATHWAYThe Imatinib-resistant PDGFR mutants pathway (Reactome ID: R-HSA-9674396) involves 1 genes and is affected by 3 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Imatinib-resistant PDGFR mutants
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | tyrphostin ag 1295 | — | 1 |
| 2 | Dasatinib | — | 299 |
| 3 | Sorafenib | — | 300 |
About the Imatinib-resistant PDGFR mutants Pathway
The Imatinib-resistant PDGFR mutants pathway is catalogued in Reactome (ID: R-HSA-9674396) and involves 1 genes. In the BiohacksAI corpus, 3 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PDGFRA.