What compounds affect the Translation of Structural Proteins pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Translation of Structural Proteins pathway (Reactome ID: R-HSA-9694635). These compounds target 9 genes within this pathway.

What genes are in the Translation of Structural Proteins pathway?

The Translation of Structural Proteins pathway involves 9 genes. Key genes include: CSNK1A1, GALNT1, GANAB, GSK3A, GSK3B, MAN2A1, PRMT1, SRPK1, SUMO1.

Translation of Structural Proteins

REACTOME PATHWAY

Reactome: R-HSA-96946359 genes47 compounds

The Translation of Structural Proteins pathway (Reactome ID: R-HSA-9694635) involves 9 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK1A1 GALNT1 GANAB GSK3A GSK3B MAN2A1 PRMT1 SRPK1 SUMO1

Compounds Affecting Translation of Structural Proteins

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	indirubin	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Kaempferols	—	300
9	Quercetin	—	300
10	chrysin	—	300
11	fisetin	—	78
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Cefixime	—	300
15	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
16	Lithium Chloride	—	300
17	ly294002	—	11
18	egcg	—	300
19	Rutin	—	300
20	Ursolic Acid	—	300
21	Oleanolic Acid	—	300
22	s adenosylhomocysteine	—	300
23	Disulfiram	—	297
24	pentamidine	—	299
25	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
26	Sulfinpyrazone	—	300
27	Calcimycin	—	216
28	cefaclor	—	299
29	Cefotetan	—	299
30	Demeclocycline	—	5
31	Ethidium	—	300
32	hydroxyindoleacetic acid	—	300
33	Metergoline	—	144
34	Nisoldipine	—	297
35	Nitrofurantoin	—	297
36	Suramin	—	300
37	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
38	Chlorhexidine	—	299
39	piceatannol	—	300
40	Cefdinir	—	298
41	Hexachlorophene	—	300
42	Oxytetracycline	—	300
43	Axitinib	—	298
44	Crizotinib	—	298
45	1-Deoxynojirimycin	—	299
46	Swainsonine	—	300
47	urolithin d	—	2

About the Translation of Structural Proteins Pathway

The Translation of Structural Proteins pathway is catalogued in Reactome (ID: R-HSA-9694635) and involves 9 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1A1, GALNT1, GANAB, GSK3A, GSK3B.