ALK mutants bind TKIs
REACTOME PATHWAYThe ALK mutants bind TKIs pathway (Reactome ID: R-HSA-9700645) involves 5 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting ALK mutants bind TKIs
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | aniracetam | — | 110 |
| 3 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
| 4 | Camptothecin | — | 300 |
| 5 | Quercetin | — | 300 |
| 6 | cycloheximide | — | 300 |
| 7 | Okadaic Acid | — | 300 |
About the ALK mutants bind TKIs Pathway
The ALK mutants bind TKIs pathway is catalogued in Reactome (ID: R-HSA-9700645) and involves 5 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALK, EIF2AK3, EML4, NPM1, PPM1B.