Negative regulation of FLT3
REACTOME PATHWAYThe Negative regulation of FLT3 pathway (Reactome ID: R-HSA-9706369) involves 3 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Negative regulation of FLT3
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | Crizotinib | — | 298 |
| 4 | tyrphostin ag 1478 | — | 4 |
| 5 | Dasatinib | — | 299 |
| 6 | pictilisib | — | 25 |
| 7 | Afatinib | — | 297 |
| 8 | tyrphostin ag 1295 | — | 1 |
| 9 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 10 | Kaempferols | — | 300 |
| 11 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 12 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 13 | Quercetin | — | 300 |
| 14 | kenpaullone | — | 8 |
| 15 | sp600125 | — | 117 |
About the Negative regulation of FLT3 Pathway
The Negative regulation of FLT3 pathway is catalogued in Reactome (ID: R-HSA-9706369) and involves 3 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL2, CSK, FLT3.