Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
REACTOME PATHWAYThe Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway (Reactome ID: R-HSA-975956) involves 3 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | egcg | — | 300 |
| 2 | Hexachlorophene | — | 300 |
| 3 | Oxytetracycline | — | 300 |
| 4 | Oxcarbazepine | — | 296 |
| 5 | Rosmarinic Acid | — | 300 |
| 6 | Rutin | — | 300 |
| 7 | Anthralin | — | 299 |
| 8 | Cefixime | — | 300 |
| 9 | Ethidium | — | 300 |
| 10 | Phenoxybenzamine | — | 21 |
| 11 | sp600125 | — | 117 |
| 12 | Temozolomide | — | 299 |
| 13 | DEAD-box RNA Helicases | — | 169 |
| 14 | Thioctic Acid | — | 298 |
| 15 | Thioctic Acid | — | 300 |
| 16 | Azauridine | — | 300 |
| 17 | Levetiracetam | — | 296 |
About the Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Pathway
The Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway is catalogued in Reactome (ID: R-HSA-975956) and involves 3 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF4G1, PABPC1, RPSA.