Chromatin modifications during the maternal to zygotic transition (MZT)
REACTOME PATHWAYThe Chromatin modifications during the maternal to zygotic transition (MZT) pathway (Reactome ID: R-HSA-9821002) involves 4 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Chromatin modifications during the maternal to zygotic transition (MZT)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | DEAD-box RNA Helicases | — | 169 |
| 2 | Thioctic Acid | — | 298 |
| 3 | Methylene Blue | — | 200 |
| 4 | Ampicillin Semi-synthetic derivative of penicillin that functions as | — | 294 |
| 5 | Cefixime | — | 300 |
| 6 | Ethidium | — | 300 |
| 7 | Levodopa | — | 297 |
| 8 | Thioctic Acid | — | 300 |
| 9 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 10 | Azacitidine | — | 298 |
| 11 | Azacitidine | — | 300 |
| 12 | Demeclocycline | — | 5 |
| 13 | Didanosine | — | 297 |
| 14 | Dinitolmide | — | 25 |
| 15 | doxylamine succinate | — | 35 |
| 16 | Methyldopa | — | 297 |
| 17 | Dequalinium | — | 136 |
| 18 | Idarubicin | — | 299 |
| 19 | Pancuronium | — | 299 |
| 20 | Phenelzine | — | 297 |
| 21 | Aurintricarboxylic Acid | — | 184 |
| 22 | isoetharine | — | 112 |
| 23 | tyrphostin 9 | — | 2 |
| 24 | Deferasirox | — | 298 |
| 25 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | — | 300 |
| 26 | triolimus [Supplementary Concept] | — | 33 |
| 27 | caffeic acid | — | 300 |
About the Chromatin modifications during the maternal to zygotic transition (MZT) Pathway
The Chromatin modifications during the maternal to zygotic transition (MZT) pathway is catalogued in Reactome (ID: R-HSA-9821002) and involves 4 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AICDA, KDM5B, KDM6B, UHRF1.