Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
REACTOME PATHWAYThe Mechanical load activates signaling by PIEZO1 and integrins in osteocytes pathway (Reactome ID: R-HSA-9856532) involves 6 genes and is affected by 20 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | oxatomide [Supplementary Concept] structure; | — | 128 |
| 2 | Flunarizine Flunarizine is | — | 299 |
| 3 | Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in | — | 299 |
| 4 | Ethosuximide | — | 297 |
| 5 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 6 | Calcimycin | — | 216 |
| 7 | Danazol | — | 298 |
| 8 | Estriol | — | 300 |
| 9 | Ezetimibe | — | 296 |
| 10 | Hexachlorophene | — | 300 |
| 11 | Loratadine | — | 296 |
| 12 | Metergoline | — | 144 |
| 13 | Nicardipine | — | 94 |
| 14 | Oxytetracycline | — | 300 |
| 15 | Ritonavir | — | 298 |
| 16 | Gabapentin | — | 295 |
| 17 | Pregabalin | — | 996 |
| 18 | Ethionine 2-Amino-4-(ethylthio)butyric acid. | — | 300 |
| 19 | Adenosine Triphosphate | — | 300 |
| 20 | Probenecid | — | 298 |
About the Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Pathway
The Mechanical load activates signaling by PIEZO1 and integrins in osteocytes pathway is catalogued in Reactome (ID: R-HSA-9856532) and involves 6 genes. In the BiohacksAI corpus, 20 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CACNA1H, CACNA2D1, ITGAV, ITGB3, P2RX7.