What compounds target CDK7?

BiohacksAI has identified 52 compounds that interact with CDK7 (cyclin dependent kinase 7). Top compounds include: gefitinib, seliciclib, alvocidib, foretinib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CDK7 (cyclin dependent kinase)?

CDK7 is cyclin dependent kinase 7. It is a molecular target for 52 compounds documented in PubMed bioassay data. NCBI Gene ID: 1022.

CDK7

MOLECULAR TARGET

cyclin dependent kinase 7

NCBI Gene: 102252 compounds

CDK7 (cyclin dependent kinase 7) is targeted by 52 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CDK7

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	seliciclib	4.91	135
3	alvocidib	4.52	91
4	foretinib	4.34	76
5	vandetanib	4.30	73
6	ruxolitinib	4.23	68
7	pi 103	4.17	64
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	bi 2536	4.01	54
11	quizartinib	3.99	53
12	dinaciclib	3.87	47
13	silmitasertib	3.78	43
14	neratinib	3.66	38
15	abemaciclib	3.66	38
16	nintedanib	3.61	36
17	bms 387032	3.47	31
18	tae 684	3.43	30
19	fedratinib	3.40	29
20	linifanib	3.33	27
21	at 7519	3.33	27
22	tandutinib	3.22	24
23	dovitinib	3.09	21
24	jnj 7706621	3.09	21
25	lestaurtinib	3.04	20
26	pf 03758309	3.00	19
27	ruboxistaurin	2.94	18
28	danusertib	2.94	18
29	defosbarasertib	2.89	17
30	r 406	2.83	16
31	milciclib	2.77	15
32	pf 00562271	2.77	15
33	pha 665752	2.71	14
34	bms 345541	2.71	14
35	azd 5438	2.71	14
36	kw 2449	2.64	13
37	ast 487	2.56	12
38	zotiraciclib	2.56	12
39	roniciclib	2.56	12
40	defactinib	2.48	11
41	gsk 461364	2.40	10
42	su 014813	2.20	8
43	ct 7001	2.20	8
44	enzastaurin	2.08	7
45	rg 547	2.08	7
46	zemirciclib	2.08	7
47	uprosertib	1.95	6
48	s roscovitine	1.95	6
49	cyc 065	1.95	6
50	hydroxyfasudil [Supplementary Concept]	1.10	2

Showing top 50 of 52 compounds. Use the BiohacksAI search to explore all CDK7 modulators.

About CDK7 as a Drug Target

CDK7 (cyclin dependent kinase 7) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 52 compounds with documented CDK7 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CDK7 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.