CGAS
MOLECULAR TARGETcyclic GMP-AMP synthase
CGAS (cyclic GMP-AMP synthase) is targeted by 15 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting CGAS
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Suramin | 2.20 | 8 |
| 2 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 1.61 | 4 |
| 3 | Aurintricarboxylic Acid | 1.61 | 4 |
| 4 | Idarubicin | 1.61 | 4 |
| 5 | Epirubicin | 1.39 | 3 |
| 6 | Daunorubicin | 1.10 | 2 |
| 7 | Hexachlorophene | 1.10 | 2 |
| 8 | Nisoldipine | 1.10 | 2 |
| 9 | egcg | 0.69 | 1 |
| 10 | amlexanox | 0.69 | 1 |
| 11 | Dequalinium | 0.69 | 1 |
| 12 | Disulfiram | 0.69 | 1 |
| 13 | Folic Acid | 0.69 | 1 |
| 14 | piromidic acid | 0.69 | 1 |
| 15 | Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. | 0.69 | 1 |
About CGAS as a Drug Target
CGAS (cyclic GMP-AMP synthase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 15 compounds with documented CGAS interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
CGAS inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.