What compounds target CHEK2?

BiohacksAI has identified 28 compounds that interact with CHEK2 (checkpoint kinase 2). Top compounds include: gefitinib, foretinib, bosutinib, doramapimod, bi 2536. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CHEK2 (checkpoint kinase 2)?

CHEK2 is checkpoint kinase 2. It is a molecular target for 28 compounds documented in PubMed bioassay data. UniProt ID: O96017. NCBI Gene ID: 11200.

CHEK2

MOLECULAR TARGET

checkpoint kinase 2

UniProt: O96017 NCBI Gene: 1120028 compounds

CHEK2 (checkpoint kinase 2) is targeted by 28 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CHEK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	foretinib	4.34	76
3	bosutinib	4.08	58
4	doramapimod	4.06	57
5	bi 2536	4.01	54
6	brigatinib	3.81	44
7	neratinib	3.66	38
8	tae 684	3.43	30
9	mln 8054	3.33	27
10	lestaurtinib	3.04	20
11	pf 03758309	3.00	19
12	hymenialdisine	3.00	19
13	ruboxistaurin	2.94	18
14	defosbarasertib	2.89	17
15	kw 2449	2.64	13
16	gsk 690693	2.64	13
17	ast 487	2.56	12
18	isogranulatimide	2.56	12
19	debromohymenialdisine	2.56	12
20	su 014813	2.20	8
21	prexasertib	2.08	7
22	sra 737	1.95	6
23	ucn 01	1.79	5
24	alsterpaullone	1.10	2
25	hydroxyfasudil [Supplementary Concept]	1.10	2
26	kenpaullone	1.10	2
27	sp600125	1.10	2
28	Lovastatin	0.69	1

About CHEK2 as a Drug Target

CHEK2 (checkpoint kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 28 compounds with documented CHEK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CHEK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.