What compounds target CSNK1E?

BiohacksAI has identified 37 compounds that interact with CSNK1E (casein kinase 1 epsilon). Top compounds include: gefitinib, erlotinib, epigalocatechin gallate, sb 203580, seliciclib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CSNK1E (casein kinase 1)?

CSNK1E is casein kinase 1 epsilon. It is a molecular target for 37 compounds documented in PubMed bioassay data. UniProt ID: P49674. NCBI Gene ID: 1454.

CSNK1E

MOLECULAR TARGET

casein kinase 1 epsilon

UniProt: P49674 NCBI Gene: 145437 compounds

CSNK1E (casein kinase 1 epsilon) is targeted by 37 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CSNK1E

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	epigalocatechin gallate	5.40	220
4	sb 203580	4.92	136
5	seliciclib	4.91	135
6	foretinib	4.34	76
7	vandetanib	4.30	73
8	bosutinib	4.08	58
9	bi 2536	4.01	54
10	neratinib	3.66	38
11	sb 202190	3.64	37
12	nintedanib	3.61	36
13	canertinib	3.53	33
14	pelitinib	3.50	32
15	bms 387032	3.47	31
16	cgs 15943	3.47	31
17	sb 431542	3.33	27
18	sp 600125	3.22	24
19	jnj 7706621	3.09	21
20	galunisertib	2.94	18
21	cediranib	2.83	16
22	milciclib	2.77	15
23	pha 665752	2.71	14
24	kw 2449	2.64	13
25	ast 487	2.56	12
26	su 014813	2.20	8
27	cyc 116	2.08	7
28	tg100 115	2.08	7
29	umbralisib	2.08	7
30	osi 632	1.79	5
31	tak 715	1.79	5
32	egcg	0.69	1
33	Afatinib	0.69	1
34	Dasatinib	0.69	1
35	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	0.69	1
36	pictilisib	0.69	1
37	sp600125	0.69	1

About CSNK1E as a Drug Target

CSNK1E (casein kinase 1 epsilon) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 37 compounds with documented CSNK1E interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CSNK1E inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.