Question 1

What compounds target DYRK2?

Accepted Answer

BiohacksAI has identified 34 compounds that interact with DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). Top compounds include: erlotinib, epigalocatechin gallate, seliciclib, foretinib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is DYRK2 (dual specificity tyrosine)?

Accepted Answer

DYRK2 is dual specificity tyrosine phosphorylation regulated kinase 2. It is a molecular target for 34 compounds documented in PubMed bioassay data. UniProt ID: Q92630. NCBI Gene ID: 8445.

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	epigalocatechin gallate	5.40	220
3	seliciclib	4.91	135
4	foretinib	4.34	76
5	ruxolitinib	4.23	68
6	pi 103	4.17	64
7	silmitasertib	3.78	43
8	abemaciclib	3.66	38
9	canertinib	3.53	33
10	6bio	3.50	32
11	bms 387032	3.47	31
12	at 7519	3.33	27
13	dovitinib	3.09	21
14	at 9283	3.09	21
15	lestaurtinib	3.04	20
16	r 406	2.83	16
17	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	2.77	15
18	plx 4720	2.71	14
19	bms 345541	2.71	14
20	kw 2449	2.64	13
21	ast 487	2.56	12
22	berzosertib	2.30	9
23	su 014813	2.20	8
24	leucettamine b	2.20	8
25	tg100 115	2.08	7
26	zemirciclib	2.08	7
27	harmol	2.08	7
28	demethylbellidifolin	1.95	6
29	lorecivivint	1.79	5
30	egcg	0.69	1
31	Afatinib	0.69	1
32	Crizotinib	0.69	1
33	pictilisib	0.69	1
34	sp600125	0.69	1

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DYRK2

Compounds Targeting DYRK2

About DYRK2 as a Drug Target