What compounds target EPHA6?

BiohacksAI has identified 32 compounds that interact with EPHA6 (EPH receptor A6). Top compounds include: gefitinib, erlotinib, sb 203580, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHA6 (EPH receptor A6)?

EPHA6 is EPH receptor A6. It is a molecular target for 32 compounds documented in PubMed bioassay data. UniProt ID: Q9UF33. NCBI Gene ID: 285220.

EPHA6

MOLECULAR TARGET

EPH receptor A6

UniProt: Q9UF33 NCBI Gene: 28522032 compounds

EPHA6 (EPH receptor A6) is targeted by 32 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHA6

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	sb 203580	4.92	136
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	nilotinib	4.17	64
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	quizartinib	3.99	53
11	sb 202190	3.64	37
12	nintedanib	3.61	36
13	canertinib	3.53	33
14	pelitinib	3.50	32
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	linifanib	3.33	27
18	mln 8054	3.33	27
19	lestaurtinib	3.04	20
20	r 406	2.83	16
21	cediranib	2.83	16
22	kw 2449	2.64	13
23	ast 487	2.56	12
24	raf 265	2.48	11
25	motesanib	2.48	11
26	brivanib	2.48	11
27	bms 754807	2.30	9
28	su 014813	2.20	8
29	rebastinib	2.20	8
30	Sorafenib	1.95	6
31	Afatinib	0.69	1
32	Crizotinib	0.69	1

About EPHA6 as a Drug Target

EPHA6 (EPH receptor A6) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 32 compounds with documented EPHA6 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHA6 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.